To be as safe as possible with Paprium, I'd recommend a genesis model 2 with an OEM power adapter.
The difficult part about clone hardware is that some of them utilize emulation and Paprium utilizes encryption of some form. I tried to dump my cart the other week just for fun and was met with encrypted garbage.
Secondly, the game runs off what I assume is an FPGA and needs extra power provided by an original Sega Adaptor, otherwise you will be met with a black screen and having to make a trip to ebay like I did.
As far as a combo system goes, eh.... your mileage may vary, I'd hate to see you waste money on a gamble.