I don't see why not. Most of the problems are easily fixable.
Still, is ASM anything like Hex editing?
In the first game, I've only fought Mame Marble, Mame Neon, Mame Runner, and Mame Crab. Mame Marble's main challenge is the lowered roof. Without it, he's still formidable, but much more reasonable. Mame Neon uses a strict pattern which isn't too hard to crack, so he's not too bad. Mame Runner is SERIOUSLY difficult because of his high-speed attack where he dashes back and forth across the room really fast, but since you can air slide to keep yourself in the air long enough to outlast the attack, it's fair enough that I'd keep it that way. ...But Mame Crab... Ugh! I tried secluding him to his starting area, but he can STILL infinitely petrify you. To make matters worse, he always summons his waves in front of you or behind so you can't count on his attacks freeing you either. All you can do is wham that keyboard in hopes you can break free. So far, Mame Crab is the only one that needs serious dire change. And I haven't even fought the other bosses. But one of them is called Mame Death, which I cannot imagine being a fair fight.