| Space Harrier II - Samples from the Arcade Game | Linkuei | Space Harrier II | Action > Shooter | GEN | S | Improvement | 0.7 | 22 Apr 2018 |
| Empire Invaders | Crush Productions | Space Invaders | Action > Shooter | NES | G | Improvement | 1.0 | 19 Aug 2005 |
| Space Invaders - Arcade | TyrannoRanger/Mr. Dude | Space Invaders | Action > Shooter | NES | G | Improvement | 1.0 | 17 Jun 2020 |
| Sanae Invaders | DASTARD | Space Invaders | Action > Shooter | NES | G, T | Improvement | 1.0 | 01 Mar 2009 |
| Space Manbow Fixes | FRS | Space Manbow | Action > Shooter | MSX | GP | Bug Fix | 1.0 | 08 Jan 2011 |
| Space Megaforce Music Patch | Revenant | Space Megaforce | Action > Shooter | SNES | S | Improvement | 1.0 | 23 Apr 2011 |
| Space Pinball Score Reset Fix | HorvatM | Space Pinball | Other | VB | O | Improvement | 1.0 | 02 Feb 2013 |
| Space Station Silicon Valley - Bug Fixes | ozidual | Space Station Silicon Valley | Action > Platformer | N64 | T, GP, O | Bug Fix | 1.2 | 21 Oct 2017 |
| Balanced Bosses | Zimgief | Sparkster | Action > Platformer | SNES | GP | Improvement | 1.0 | 05 Jan 2020 |
| Enable hidden characters | [John] | Spectral VS Generation | Action > Fighting | PS2 | O | Improvement | 1.0 | 29 Jun 2019 |
| Speedy Gonzales - Level 6-1 bugfix | sluffy | Speedy Gonzales in Los Gatos Bandidos | Action > Platformer | SNES | O | Bug Fix | 20181102 | 11 Feb 2018 |
| Spellcaster - SRAM save | Ichigobankai | Spellcaster | Role Playing > Action RPG | SMS | O | Improvement | 1.0 | 20 Aug 2017 |
| Spelunker Yukkuri | DASTARD | Spelunker | Action > Platformer | NES | G | Improvement | 1.0 | 01 Feb 2009 |
| Marilunker | Tsurumidou | Spelunker | Action > Platformer | NES | G, T | Improvement | 1.0 | 01 Jan 1999 |
| Spelunker: Don't Skip Leg Day | famiclone | Spelunker | Action > Platformer | NES | GP | Improvement | 1.0 | 26 Aug 2020 |
| Spider-Man: Return of the Sinister Six color fix | wolfamancer97 | Spider-Man: Return of the Sinister Six | Action > Platformer | NES | G, O | Improvement | final | 05 Apr 2019 |
| Splatterhouse Chrome | guemmai | Splatterhouse | Action > Beat 'Em Up | TG16 | G, L, GP | Complete | 1.0 | 13 Jan 2009 |
| Splatterhouse 2 "classic mask" Rick and color hack | fusaru | Splatterhouse 2 | Action > Beat 'Em Up | GEN | G | Improvement | 1.00 | 16 Apr 2016 |
| SD Splatterhouse MMC-3 Hack | MottZilla | Splatterhouse: Wanpaku Graffiti | Action | NES | O | Improvement | 1.2 | 19 Jul 2008 |
| Evil Dead: Ash lives! | Crying Onion | Splatterhouse: Wanpaku Graffiti | Action | NES | G, T, O | Complete | 1.0 | 23 Apr 2020 |
