| Spelunker: Don't Skip Leg Day | famiclone | Spelunker | Action > Platformer | NES | GP | Improvement | 1.0 | 26 Aug 2020 |
| Spelunker Yukkuri | DASTARD | Spelunker | Action > Platformer | NES | G | Improvement | 1.0 | 01 Feb 2009 |
| Spellcaster - SRAM save | Ichigobankai | Spellcaster | Role Playing > Action RPG | SMS | O | Improvement | 1.0 | 20 Aug 2017 |
| Spell Name Update | Almagest | Breath of Fire III | Role Playing | PSX | T | Improvement | 1.0 | 26 Sep 2016 |
| Spell Name Modernization Patch | Reiska | Dragon Warrior III | Role Playing | NES | T | Improvement | 1.1 | 16 May 2012 |
| Spell Bugfix | Chicken Knife | Dragon Warrior III | Role Playing | NES | GP | Bug Fix | 1.01 | 02 Aug 2021 |
| Spell Balance Overhaul | hmsong | Secret of Mana | Role Playing > Action RPG | SNES | GP | Improvement | 0.6 | 08 Apr 2020 |
| Spekkio Lufia | Artemis | Lufia II: Rise of the Sinistrals | Role Playing | SNES | G, T, GP, O | Improvement | 6.0 | 09 Nov 2022 |
| Speedy Gonzales - Level 6-1 bugfix | sluffy | Speedy Gonzales in Los Gatos Bandidos | Action > Platformer | SNES | O | Bug Fix | 20181102 | 11 Feb 2018 |
| Speedrun Timer | fractal161 | Tetris | Puzzle | NES | G, O | Improvement | 1.0 | 08 Jun 2022 |
| Speedrun Boss Rush Neutopia II | sveniroth | Neutopia II | Action Adventure | TG16 | O | Improvement | 1.0 | 02 Mar 2021 |
| Speedrun Boss Rush | sveniroth | Neutopia | Action Adventure | TG16 | L | Improvement | 1.0 | 20 Jul 2020 |
| Speedhack | fractal161 | Tetris | Puzzle | NES | G, GP | Improvement | 1.0 | 26 Aug 2022 |
| Speed optimization | MagnetFirstBro | Mega Man 5 | Action > Platformer | NES | O | Improvement | 1.0 | 08 Aug 2022 |
| Spatterhouse NES - Featuring Michael Jackson | Jack_Vincent13 | Splatterhouse: Wanpaku Graffiti | Action | NES | G | Improvement | 1.0 | 27 Jul 2020 |
| Space Station Silicon Valley - Bug Fixes | ozidual | Space Station Silicon Valley | Action > Platformer | N64 | T, GP, O | Bug Fix | 1.2 | 21 Oct 2017 |
| Space Pinball Score Reset Fix | HorvatM | Space Pinball | Other | VB | O | Improvement | 1.0 | 02 Feb 2013 |
| Space Megaforce Music Patch | Revenant | Space Megaforce | Action > Shooter | SNES | S | Improvement | 1.0 | 23 Apr 2011 |
| Space Manbow Fixes | FRS | Space Manbow | Action > Shooter | MSX | GP | Bug Fix | 1.0 | 08 Jan 2011 |
| Space Invasion - hardware compatibility | Radiant_Nighte | Space Invasion | Action > Shooter | GB | O | Bug Fix | 0.1 | 19 Sep 2022 |
