| Spyro: Season of Ice DX | Cornholio309 | Spyro Advance | Action > Platformer | GBA | G, T, GP | Addendum | 1.01 | 31 Jan 2022 |
| Spyro 2 - Ripto's Rage: Yardrat Edition | Unicorngoulash | Spyro 2 - Ripto's Rage | Adventure | PSX | GP | Addendum | 1.0 | 10 Apr 2022 |
| Spy Hunter CNROM to MMC3 Hack | infidelity | Spy Hunter | Racing | NES | O | Improvement | 1.0 | 30 Nov 2013 |
| Spudd - The Journey Home | Montagna | Super Mario Bros. | Action > Platformer | NES | G, L | Complete | 1.0 | 01 Jan 2000 |
| Sprite Bugfix | Chicken Knife | Dragon Warrior III | Role Playing | NES | G | Bug Fix | 1.0 | 02 May 2020 |
| Spooky Mission 2: The Nightmare Before Christmas | Spooky Team | Metroid: Zero Mission | Action > Platformer | GBA | G, S, L, T, GP, O | Complete | 1.2a | 07 Aug 2022 |
| Splatterhouse Chrome | guemmai | Splatterhouse | Action > Beat 'Em Up | TG16 | G, L, GP | Complete | 1.0 | 13 Jan 2009 |
| Splatterhouse 3: Bloody Edition | CRT_rex | Splatterhouse 3 | Action > Beat 'Em Up | GEN | G | Improvement | 1.2 | 06 Oct 2021 |
| Splatterhouse 3 SRAM | BillyTime! Games | Splatterhouse 3 | Action > Beat 'Em Up | GEN | O | Improvement | 1.1 | 23 Apr 2021 |
| Splatterhouse 2 - Score Bonus | BillyTime! Games | Splatterhouse 2 | Action > Beat 'Em Up | GEN | GP | Improvement | 1.0 | 18 Mar 2022 |
| Splatterhouse 2 "classic mask" Rick and color hack | fusaru | Splatterhouse 2 | Action > Beat 'Em Up | GEN | G | Improvement | 1.00 | 16 Apr 2016 |
| Spirit bug fix | Gemini | Final Fantasy VII | Role Playing | PSX | GP | Bug Fix | 1.0 | 09 Jan 2009 |
| Spiny Egg Behavior Fix for SMB1 and Lost Levels | ZeroShift | Super Mario All-Stars | Action > Platformer | SNES | GP | Bug Fix | 1.1 | 12 Dec 2016 |
| Spiny Dodge Ball | Googie | Super Dodge Ball | Sports | NES | G, T | Improvement | 1.0 | 12 Sep 2005 |
| Spike McFang Uniblonde Restoration | jackic | The Twisted Tales of Spike McFang | Role Playing > Action RPG | SNES | G | Improvement | 1.0 | 02 Feb 2022 |
| Spider-Man: Return of the Sinister Six color fix | wolfamancer97 | Spider-Man: Return of the Sinister Six | Action > Platformer | NES | G, O | Improvement | final | 05 Apr 2019 |
| Spider-Man: Homecoming | fex34 | Ninja Five-O | Action > Platformer | GBA | G, S | Complete | 1.0 | 25 Jul 2022 |
| Spider-Man VS Kingpin DX | BillyTime! Games | Spider-Man vs. The Kingpin | Action > Platformer | GEN | G, GP, O | Improvement | 1.3 | 31 Dec 2021 |
| Spider-Man / X-Men - Arcade's Redux | BillyTime! Games | Spider-Man/X-Men - Arcade's Revenge | Action > Platformer | GEN | S, T, GP | Improvement | 1.0 | 16 Dec 2020 |
| Spider Wars | Mitz | Battle City | Action | NES | G, L | Complete | 1.0 | 19 Jun 2011 |
