| Skeens Super Mario Bros | Micheil Skeens | Super Mario Bros. | Action > Platformer | NES | G, L | Complete | 1.0 | 01 Mar 2017 |
| Skate or Die MMC5 Patch | Dracula X | Skate or Die | Sports | NES | O | Improvement | 1.0 | 21 May 2020 |
| Sirius Mario Bros. 6 | Sirius | Super Mario Bros. | Action > Platformer | NES | L | Complete | 1.0 | 01 Jan 2000 |
| Sirius Mario Bros. 5 | Sirius | Super Mario Bros. | Action > Platformer | NES | L | Complete | 1.0 | 01 Jan 2000 |
| Sirius Mario Bros. 4 | Sirius | Super Mario Bros. | Action > Platformer | NES | L | Complete | 1.0 | 01 Jan 2000 |
| Sirius Mario Bros. 3 | Sirius | Super Mario Bros. | Action > Platformer | NES | L | Complete | 1.0 | 01 Jan 2000 |
| Sirius Mario Bros. 2 | Sirius | Super Mario Bros. | Action > Platformer | NES | L | Complete | 1.0 | 01 Jan 2000 |
| Sirius Mario Bros. 1 | Sirius | Super Mario Bros. | Action > Platformer | NES | L | Complete | 1.0 | 01 Jan 2000 |
| Simultaneous movement removal patch | denim | Vandal Hearts II | Strategy > Turn Based | PSX | GP | Improvement | 1.0 | 06 Jan 2022 |
| Simplified with Druid Dagger Fix | magus | Robin Hood: Prince of Thieves | Role Playing | NES | GP | Improvement | 1.0 | 25 Aug 2016 |
| Simplified Hidden Vs mode | Docrow | Super Punch-Out!! | Action > Fighting | SNES | GP | Improvement | 1.0 | 14 Aug 2022 |
| Simple DAS Trainer | rlnilsen | Tetris | Puzzle | NES | G, T, O | Improvement | 1.3 | 23 Oct 2020 |
| Simon's Redaction | The Almighty Guru | Castlevania II: Simon’s Quest | Role Playing > Action RPG | NES | G, T, GP | Improvement | 1.0 | 15 Dec 2011 |
| Simon's Quest: Lame Edition | Optomon | Castlevania II: Simon’s Quest | Role Playing > Action RPG | NES | L, T, GP | Complete | 1.0 | 23 May 2010 |
| Simon LoS Mirror of Fate in Harmony of Dissonance | Dom Jurumela | Castlevania: Harmony of Dissonance | Role Playing > Action RPG | GBA | G | Improvement | 1.0 | 04 Jun 2021 |
| SimCity - Fastrom | kandowontu | SimCity | Simulation | SNES | GP | Improvement | 1.0 | 10 Feb 2023 |
| SimAnt - Fastrom | kandowontu | SimAnt: The Electronic Ant Colony | Simulation | SNES | GP | Improvement | 1.0 | 05 Mar 2023 |
| Sim City - Sylt Map | lytron | SimCity | Simulation | SNES | O | Complete | 1.0 | 25 Oct 2014 |
| Silver Surfer Super Cheats | dougeff | Silver Surfer | Action > Shooter | NES | GP | Improvement | 1.0 | 12 Feb 2016 |
| Silver Surfer - AutoFire | MottZilla | Silver Surfer | Action > Shooter | NES | GP | Improvement | 1.0 | 16 Feb 2015 |
