| Remove Erdrick Block | Darrman | Dragon Warrior III | Role Playing | NES | T | Improvement | 1.0 | 22 May 2020 |
| Remove Empire Castle Gate Permanently | Kethinov | Secret of Mana | Role Playing > Action RPG | SNES | GP | Improvement | 1.4 | 12 Nov 2019 |
| Remove Barrels on Run | Kethinov | Secret of Mana | Role Playing > Action RPG | SNES | GP | Improvement | 1.2 | 29 Dec 2019 |
| Remix of Tiny Toon Adventures | Razor | Tiny Toon Adventures | Action > Platformer | NES | L | Complete | 1.2 | 25 Dec 2017 |
| Reload City | Dark Reaper | Battle City | Action | NES | G, L, T | Complete | 1.0 | 13 Nov 2012 |
| Reimu in Streets of Rage 2 | Mystery Hacks | Streets of Rage 2 | Action > Beat 'Em Up | GEN | G, S | Improvement | 1.0 | 13 Nov 2017 |
| Reign of the Koopa (Hack 1 of 10) | willj168 | Super Mario Bros. | Action > Platformer | NES | G, L, T | Complete | 1.1 | 24 Jun 2010 |
| Region switch | [John] | RockMan: Power Battle Fighters | Action > Fighting | PS2 | T, O | Improvement | 1.0 | 22 Jul 2019 |
| Region Lockout Removal | LucianoTheWindowsFan | Hashire Hebereke | Racing | SNES | O | Improvement | 1.0 | 04 Aug 2020 |
| Regen Power-up Patch | Phoenix Hacks | Final Fantasy II | Role Playing | SNES | GP | Improvement | 1.0 | 12 Apr 2008 |
| Reflections | Leet Sketcher | Final Fantasy III | Role Playing | SNES | G | Bug Fix | 1.1 | 25 Apr 2016 |
| Refined Platinum | Refined Platinum | Pokémon: Platinum Version | Role Playing | NDS | L, T, GP | Improvement | 3.3.1 | 13 Nov 2021 |
| Refined Gold | Refined Platinum | Pokémon: HeartGold Version | Role Playing | NDS | T, GP | Improvement | 2.0.2 | 12 Nov 2021 |
| Refill Weapon after Death | Thirteen 1355 | Mega Man | Action > Platformer | NES | GP | Improvement | 1.0 | 18 Sep 2019 |
| Refill Weapon after Death | Thirteen 1355 | Mega Man 2 | Action > Platformer | NES | GP | Improvement | 1.0 | 24 Sep 2019 |
| Refill Weapon after Death | Thirteen 1355 | Mega Man 3 | Action > Platformer | NES | GP | Improvement | 1.0 | 27 Sep 2019 |
| Refill Weapon after Death | Thirteen 1355 | Mega Man: Dr. Wily's Revenge | Action > Platformer | GB | GP | Improvement | 1.0 | 04 Oct 2019 |
| Refill Weapon after Death | Thirteen 1355 | Mega Man II | Action > Platformer | GB | GP | Improvement | 1.0 | 07 Oct 2019 |
| Refill Weapon after Death | ElwinBran | Mega Man 4 | Action > Platformer | NES | GP | Improvement | 1.0 | 10 Oct 2019 |
| Refill Weapon after Death | Thirteen 1355 | Mega Man III | Action > Platformer | GB | GP | Improvement | 1.0 | 13 Oct 2019 |
