| Emeraldia | No Alternate Title | NAMCO | 01 July 1993 | Puzzle | ARC | N | N | N | Y |
| Emily The Strange: Strangerous | No Alternate Title | Conspiracy Entertainment | 24 May 2011 | Adventure | NDS | N | Y | Y | N |
| Emoyan no 10 Bai Pro Yakyuu | Emoto's Pro Baseball - 10x More Fun! | Hect | 19 December 1989 | Sports | NES | N | N | Y | N |
| Enduro Racer | Super Cross | Sega | 18 May 1987 | Racing | SMS | N | N | Y | N |
| Energy | No Alternate Title | NCS | 19 April 1989 | Action > Platformer | TG16 | N | N | Y | N |
| Energy Breaker | No Alternate Title | Taito | 26 July 1996 | Role Playing | SNES | N | N | Y | N |
| Equinox | Solstice II | Sony | 12 November 1993 | Role Playing | SNES | Y | N | N | N |
| Erika to Satoru no Yume Bouken | Erika and Satoru's Dream Adventure | Namco | 27 September 1988 | Adventure | NES | N | N | Y | Y |
| Esper Boukentai | Esper Corps | Jaleco | 13 October 1987 | Action > Platformer | NES | N | N | Y | N |
| Esper Dream | No Alternate Title | Konami | 20 February 1987 | Role Playing > Action RPG | FDS | N | N | Y | N |
| Esper Dream 2: Aratanaru Tatakai | No Alternate Title | Konami | 26 June 1992 | Role Playing > Action RPG | NES | N | N | Y | N |
| ESWAT: City Under Siege | Cyber Police ESWAT | Sega | 14 July 1990 | Action > Platformer | GEN | N | N | Y | N |
| Eternal Champions | No Alternate Title | Sega | 11 December 1993 | Action > Fighting | GEN | Y | N | N | Y |
| Eternal Champions - Challenge From The Dark Side | No Alternate Title | Sega | 12 September 1994 | Action > Fighting | SegaCD | N | N | Y | Y |
| Eternal Legend | No Alternate Title | Sega | 09 August 1991 | Role Playing | GG | N | N | Y | N |
| Evil Twin: Cyprien's Chronicles | No Alternate Title | Ubisoft | 12 April 2002 | Action > Platformer | DC | N | N | Y | N |
| Evolution Worlds | No Alternate Title | Ubisoft | 02 December 2002 | Role Playing | GC | N | N | N | Y |
| Evolution: Eternal Dungeons | Shinkisekai Evolution: Hateshinai Dungeon | SNK | 10 February 2000 | Role Playing | NGPC | N | N | Y | N |
| Ex-Mutants | No Alternate Title | Sega | 1992 | Action > Platformer | GEN | Y | N | N | N |
| eXceed: Gun Bullet Children | No Alternate Title | Capcom | 2005 | Action > Shooter | PC | N | N | Y | N |
