| Sei Shoujou Sentai Lakers III | Battle Team Lakers III | Apple Pie | 26 April 1996 | Strategy > Turn Based | PC98 | N | N | N | N |
| Seicross | No Alternate Title | Nihon Bussan | 19 May 1986 | Action > Shooter | NES | N | N | Y | Y |
| Seiken Acho | No Alternate Title | ASCII Corporation | 1985 | Action > Fighting | MSX | N | N | Y | N |
| Seiken Psycho Caliber: Maju no Mori Densetsu | Seiken Psycho Calibur | Imagineer | 19 May 1987 | Role Playing > Action RPG | FDS | N | N | Y | Y |
| Seiko-Chan SOS | No Alternate Title | Cosmic Soft | 1983 | Action > Shooter | PC88 | N | N | Y | N |
| Seirei Gari | Ghost Hunter | Hudson | 08 December 1989 | Adventure | NES | N | N | Y | N |
| Sengoku Anthology | No Alternate Title | SNK Playmore | 01 September 2009 | Action > Beat 'Em Up | PS2 | N | N | N | Y |
| Sengoku BASARA X | 戦国BASARA X | CAPCOM | 09 April 2008 | Action > Fighting | PS2 | N | N | N | Y |
| Sengoku Denshou | No Alternate Title | Data East | 19 September 1993 | Action > Beat 'Em Up | SNES | N | N | Y | N |
| Senjou no Valkyria 3: Extra Edition | Valkyria Chronicles 3: Extra Edition | Sega | 23 November 2011 | Strategy > Turn Based | PSP | N | N | Y | N |
| Senjyo | No Alternate Title | Tehkan | 1983 | Action > Shooter | ARC | N | N | Y | N |
| Senjyo | No Alternate Title | Sony | 1984 | Action > Shooter | MSX | N | N | Y | N |
| Sensible Soccer: European Champions | No Alternate Title | Sega | 1988 | Sports | SMS | N | N | Y | N |
| Sensible Soccer: European Champions | No Alternate Title | Sony | 1993 | Sports | GB | N | N | Y | N |
| Sesame Street: ABC | No Alternate Title | Hi Tech Expressions | September 1989 | Other | NES | N | N | Y | N |
| Seven Mansions: Ghastly Smile | Nanatsu no Hikan: Senritsu no Bishou | Koei | 20 January 2000 | Action > Shooter | DC | N | N | Y | N |
| Shadow Blasters | Shiten Myouou | Sage's Creation | 09 August 1990 | Action > Platformer | GEN | N | N | Y | N |
| Shadow Brain | No Alternate Title | Pony Canyon | 21 March 1991 | Role Playing | NES | N | N | Y | N |
| Shadow Dancer | Shadow Dancer: The Secret of Shinobi | Sega | 1990 | Action | GEN | N | N | Y | Y |
| Shadow Man: 2econd Coming | No Alternate Title | Acclaim Entertainment | 28 February 2002 | Action Adventure | PS2 | N | N | N | Y |
