| Resident Evil: Director's Cut | Biohazard: Director's Cut | Capcom | 25 September 1997 | Action Adventure | PSX | N | N | Y | Y |
| Resident Evil: Deadly Silence | BioHazard: Deadly Silence | Capcom | 19 January 2006 | Action Adventure | NDS | N | N | Y | N |
| Resident Evil Zero | Biohazard Zero | Capcom | 12 November 2002 | Action Adventure | GC | N | Y | N | N |
| Resident Evil 5 | BioHazard 5 | Capcom | 15 June 2009 | Action > Shooter | PC | Y | N | Y | N |
| Resident Evil 3: Nemesis | Biohazard 3: Last Escape | Capcom | 22 September 1999 | Action | PSX | N | N | Y | N |
| Resident Evil 2: DualShock Ver. | Biohazard 2: DualShock Ver. | Capcom | 21 January 1998 | Action | PSX | N | N | Y | N |
| Resident Evil 2 | BioHazard 2 | Capcom | 22 December 1999 | Action Adventure | DC | N | N | Y | N |
| Resident Evil (Prototype) | No Alternate Title | Capcom | 2000 | Adventure | GB | N | N | Y | Y |
| Resident Evil | Biohazard | Virgin Interactive | 30 September 1997 | Action Adventure | PC | N | N | N | Y |
| Rescue: The Embassy Mission | Hostages: The Embassy Mission | Kemco | 01 December 1989 | Action > Shooter | NES | N | N | Y | N |
| Rescue Mission | No Alternate Title | Sega | 1988 | Action > Shooter | SMS | N | N | Y | N |
| Rent a Hero | No Alternate Title | Sega | 20 September 1991 | Role Playing | GEN | N | N | Y | N |
| Renegade | No Alternate Title | Sega | 1993 | Action > Beat 'Em Up | SMS | N | N | Y | N |
| Renegade | Nekketsu Kouha Kunio-kun; River City Ransom Zero | Technos | 17 April 1987 | Action > Beat 'Em Up | NES | Y | N | Y | Y |
| Remote Control Dandy | No Alternate Title | Human | 22 July 1999 | Action | PSX | N | N | Y | N |
| Remember11: The Age of Infinity | No Alternate Title | CyberFront | 19 September 2008 | Visual Novel | PC | N | N | Y | N |
| Regulus | No Alternate Title | Sega | 1983 | Action > Shooter | ARC | N | N | Y | N |
| Red Zone | No Alternate Title | Time Warner Interactive | 1994 | Action > Shooter | GEN | N | N | Y | N |
| Red vs. Blue | No Alternate Title | Atari | 1981 | Sports | 2600 | Y | N | N | N |
| Red Riding Hood Chacha | Akazukin Chacha | Tomy | 09 August 1996 | Role Playing | SNES | N | N | N | N |
