| Shadow Warriors | Ninja Ryukenden GB; Ninja Gaiden Shadow | Tecmo | 13 December 1991 | Action > Platformer | GB | N | N | Y | N |
| Shadow Watch | No Alternate Title | Red Storm Entertainment | 31 March 2000 | Strategy > Turn Based | PC | N | N | Y | N |
| Shadowgate | No Alternate Title | Kemco | 31 March 1989 | Adventure | NES | N | N | Y | Y |
| Shadowhawk | No Alternate Title | Studio E | Unreleased | Action > Beat 'Em Up | SNES | N | N | N | Y |
| Shadowrun | No Alternate Title | Sega | 1994 | Role Playing > Action RPG | GEN | N | N | N | Y |
| Shadowrun | No Alternate Title | Data East | 01 May 1993 | Role Playing > Action RPG | SNES | N | Y | N | N |
| Shalom: Knightmare III | No Alternate Title | Konami | 1987 | Role Playing | MSX | N | N | Y | N |
| Shaman King: Master of Spirits | No Alternate Title | Konami | 09 November 2004 | Action > Platformer | GBA | N | N | Y | N |
| Shaman King: Master of Spirits 2 | No Alternate Title | Konami | 02 August 2005 | Action > Platformer | GBA | N | N | Y | N |
| Shanghai | No Alternate Title | Sega | 1988 | Boardgame | SMS | N | N | Y | N |
| Shanghai | No Alternate Title | Hudson | 30 October 1987 | Puzzle | TG16 | N | N | Y | N |
| Shanghai | No Alternate Title | HAL Labs | 28 July 1989 | Puzzle | GB | N | N | Y | N |
| Shanghai Pocket | No Alternate Title | Activision | December 1998 | Puzzle | GB | N | N | Y | N |
| Shantae | No Alternate Title | Capcom | 02 June 2002 | Action > Platformer | GB | N | Y | Y | Y |
| Shaq Fu | No Alternate Title | Electronic Arts | 1994 | Action > Fighting | SNES | N | N | Y | Y |
| Shatterhand | Tokkyuu Shirei: Solbrain;Directive: Solbrain;Super Rescue: Solbrain | Angel Studios | 26 October 1991 | Action > Platformer | NES | N | N | Y | Y |
| Shenmue | Shenmue Chapter 1: Yokosuka | Sega | 29 December 1999 | Action Adventure | DC | N | Y | Y | N |
| Shenmue II | No Alternate Title | Sega-AM2 | 06 September 2001 | Action Adventure | DC | N | N | Y | N |
| Shenmue II | No Alternate Title | Sega | 28 October 2002 | Action Adventure | XBOX | N | N | Y | N |
| Sherlock Holmes: Hakushaku Reijou Yuukai Jiken | Sherlock Holmes: The Kidnapped Countess | Towa Chiki | 11 December 1986 | Action > Platformer | NES | N | N | Y | N |
