| Zaxxon | No Alternate Title | Pony Canyon | 1985 | Action > Shooter | MSX | N | N | Y | N |
| Zaxxon | No Alternate Title | Sega | 1985 | Action > Shooter | SG1K | N | N | Y | N |
| Zelda II: The Adventure of Link | No Alternate Title | Nintendo | 26 September 1988 | Role Playing > Action RPG | NES | Y | Y | Y | Y |
| Zelda no Densetsu: The Hyrule Fantasy | The Legend of Zelda | Nintendo | 21 February 1986 | Action Adventure | FDS | N | N | Y | Y |
| Zen: Intergallactic Ninja | No Alternate Title | Konami | 07 March 1993 | Action > Platformer | NES | N | N | Y | N |
| Zenkoku Juudan Ultra Shinri Game | No Alternate Title | Visit | 10 November 1995 | Other | SNES | N | N | N | Y |
| Zero the Kamikaze Squirrel | No Alternate Title | SunSoft | 1994 | Action > Platformer | GEN | N | N | Y | N |
| Zero the Kamikaze Squirrel | No Alternate Title | SunSoft | November 1994 | Action > Platformer | SNES | N | N | Y | N |
| Zero Tolerance | No Alternate Title | Accolade | 1994 | Action | GEN | N | Y | Y | Y |
| Zero Wing | No Alternate Title | Sega | 31 May 1991 | Action > Shooter | GEN | N | N | Y | Y |
| Zero: Tsukihami no Kamen | Fatal Frame IV; Fatal Frame 4: Mask of the Lunar Eclipse | Nintendo | 31 July 2008 | Action Adventure | WII | N | N | Y | N |
| Zettai Muteki Raijin-Oh | Absolute Invincible Raijin-Oh | Tomy | 28 December 1991 | Action > Fighting | GB | N | N | Y | Y |
| Zexas Limited | No Alternate Title | dB-SOFT | 1985 | Action > Shooter | MSX | N | N | Y | N |
| Zhen Jia Hou Wang | Genuine Monkey | Fuzhou Waixing Computer Science & Technology | 1999 | Action > Platformer | NES | N | N | Y | N |
| Zheng Jiu Shi Ji | Guang Ming Zhi Shen | Fuzhou Waixing Computer Science & Technology Co.,LTD | 2006 | Action Adventure | NES | N | N | Y | N |
| Zhong Guo Xiang Qi | Chinese Chess | TXC Corp | 1991 | Boardgame | NES | N | N | Y | N |
| Zill O'll Infinite | No Alternate Title | Koei | 23 June 2005 | Role Playing | PS2 | N | N | Y | N |
| Zillion | Akai Koudan Zillion | Sega | 24 May 1987 | Action | SMS | N | N | Y | Y |
| Zippy Race | No Alternate Title | Irem | 18 July 1985 | Racing | NES | N | N | Y | Y |
| Zippy Race | No Alternate Title | Sega | 1983 | Racing | SG1K | N | N | Y | Y |
