| U.N. Squadron | Area 88 | Capcom | 26 July 1991 | Action > Shooter | SNES | N | N | Y | Y |
| Uchuu no Kishi Tekkaman Blade | Space Knight Tekkaman Blade | Interbec | 1993 | Action | SNES | N | N | Y | N |
| Uchuu Senkan Gomora | No Alternate Title | UPL | 30 September 1991 | Action > Shooter | GEN | N | N | N | Y |
| Uchuujin Tanaka Tarou de RPG Tsukuru GB2 | RPG Maker GB2 | Enterbrain | 20 July 2001 | Game Creation | GB | N | N | Y | N |
| Uchuusen Cosmo Carrier | No Alternate Title | Jaleco | 06 November 1987 | Action > Shooter | NES | N | N | Y | N |
| Ultima: Exodus | Ultima: Kyoufu no Exodus | Pony Canyon | 09 October 1987 | Role Playing | NES | N | Y | N | Y |
| Ultima: Quest of the Avatar | Ultima: Seisha e no Michi | Pony Canyon | 20 September 1989 | Role Playing | NES | Y | Y | N | N |
| Ultima: Runes of Virtue | Ultima: Ushinawareta Runes | FCI | 14 December 1991 | Role Playing > Action RPG | GB | N | N | N | Y |
| Ultimate Fighter | Hiryu no Ken S: Golden Fighter | Culture Brain | 31 July 1992 | Action > Beat 'Em Up | SNES | N | N | Y | N |
| Ultimate Mortal Kombat 3 | No Alternate Title | Midway | 11 October 1996 | Action > Fighting | SNES | N | N | N | Y |
| Ultimate Mortal Kombat 3 | No Alternate Title | Williams | 1996 | Action > Fighting | GEN | N | N | N | Y |
| Ultimate Qix | Volfied | Taito | 1991 | Action | GEN | N | N | Y | N |
| Ultimate Spider-Man | No Alternate Title | Activision | 19 September 2005 | Action > Platformer | GBA | N | N | Y | N |
| Ultra Baseball Jitsumeiban | No Alternate Title | Culture Brain | 28 August 1992 | Sports | SNES | N | N | Y | N |
| Ultraman Ball | No Alternate Title | Bec | 22 December 1994 | Action > Platformer | GB | N | N | Y | N |
| Ultraman Chou Toushi Gekiden | Ultraman: Legend of the Super Warrior | Angel | 26 August 1994 | Action | GB | N | N | Y | N |
| Ultraman Club: Kaijuu Daikessen!! | Ultraman Club: Great Kaiju Battle | Angel (Bandai) | 25 December 1992 | Action > Platformer | NES | N | N | Y | N |
| Umihara Kawase | No Alternate Title | TNN | 23 December 1994 | Action > Platformer | SNES | N | N | Y | Y |
| Undead Line | No Alternate Title | PalSoft | 20 December 1991 | Action > Shooter | GEN | N | N | Y | N |
| Undeadline: Genjuuki | No Alternate Title | T&E Soft | 27 September 1990 | Action > Shooter | X68K | N | N | Y | N |
