It's not that hard, but due to the small size it would be more of a passing resemblance, or you'd have to change the monster bodies into just walking heads.
OMG I laughed so hard when I saw that image!
Oh okay I see what you mean. Would it be hard to edit the heads into Trump and Pence with what's already available?
Hack request for:https://uploadfiles.io/t6hgarf2
Shinobi III: Return of the Ninja Master (Genesis/Mega Drive)
You can switch back to 3 button mode by holding C + Start on controller 1 when you enter the options menu.