Medfaden is probably the best PCE Emulator, it's just that for some unknown reason it completely refuses to run on my PC, not even an error message or anything, it just does nothing when I try to launch it.
For hucard roms or for CD ISO games? For roms, I just associate the file extension in windows to the exe file. Cutting out the need for command line options. Of course I have everything setup in the CFG file for filtering and scanlines too.
For CD games, you need to setup the command line just once, or at least manually edit the CFG once - for the BIOS rom to run them. Then, do like with PCE files and just associate CUE files with the mednafen.exe file in windows. Instant launch when you double click the CUE file. If the emulator itself has a problem trying to load/run a game, it outputs a std.txt or err.txt or some file like that. And it's usually placed in the directory of the file you're trying to run (assuming you've setup the EXE as an association file type for the rom).
Yeah, that emulator Bizhawk looks like it's for TAS type stuff - not a debugger. I recognize one authors on the project too, that hangs out in the mednafen channel.
A little demo of the sprite work:
I originally was hacking the meta tile related stuff for the sprites, but I've decided that I'm just gonna put a hook in there instead and read from my own tables - to write to $200 for sprite DMA (NES side).