| Sorcerian | SSTranslations | Role Playing | GEN | Unfinished | 0.5 | 24 Jul 2009 | EN |
| Sorcerian | Delta Soft | Role Playing > Action RPG | MSX | Fully Playable | 1.0 | 27 Aug 2003 | EN |
| Sorcerian Forever | MrRichard999 | Role Playing > Action RPG | PC | Unfinished | 0.51b | 16 Aug 2016 | EN |
| Sore Ike! Anpanman - Minna de Hiking Game! | Pope Hentai's Rom Hacking Fun! | Boardgame | NES | Unfinished | 0.99 | 12 Aug 2004 | EN |
| Soreyuke Ebisumaru Karakuri Meiro - Kieta Goemon no Nazo!! | DDSTranslation | Puzzle | SNES | Fully Playable | 2.0 | 26 Aug 2020 | EN |
| Soul Blazer | Steppolo Steppi | Role Playing > Action RPG | SNES | Fully Playable | 1.1 | 19 Feb 2018 | EN |
| Soul Eater: Medusa no Inbou | Anime Game Translations Team | Action | NDS | Fully Playable | 1.1 | 31 May 2020 | EN |
| Soul Getter: Houkago Bouken RPG | MageCraft Translations | Role Playing | GB | Unfinished | 0.10 | 28 Oct 2000 | EN |
| Space Fantasy Zone | Naflign's Ego | Action > Shooter | TGCD | Unfinished | a01 | 20 Sep 2000 | EN |
| Space Hunter | Zatos Hacks | Action Adventure | NES | Fully Playable | 1.0 | 23 May 2018 | EN |
| Space Squash | Feel | Sports | VB | Unfinished | 1.0 | 07 Aug 2007 | EN |
| Space Squash | Feel, KR155E | Sports | VB | Fully Playable | 2.0 | 02 Jun 2013 | EN |
| Spartan X 2 | Abstract Crouton Productions | Action | NES | Fully Playable | 1.0 | 07 Mar 2003 | EN |
| Spelunker II: Yuushahe no Chousen | Sarysa | Role Playing > Action RPG | NES | Fully Playable | 0.9 | 20 Mar 2003 | EN |
| Spelunker II: Yuushahe no Chousen | Stardust Crusaders | Role Playing > Action RPG | NES | Fully Playable | 1.0 | 18 Feb 2011 | EN |
| Splatterhouse: Wanpaku Graffiti | Spinner 8 and friends | Action | NES | Fully Playable | 2.0 | 07 Jan 2000 | EN |
| Sqoon | Stardust Crusaders | Action > Shooter | NES | Fully Playable | 1.0 | 19 Feb 2010 | EN |
| Square no Tom Sawyer | Kikuyama | Role Playing | NES | Unfinished | 0.07 | 10 Dec 1998 | EN |
| Square no Tom Sawyer | Dushbadge | Role Playing | NES | Unfinished | 2.0 | 14 Aug 2016 | EN |
| Squashed | HTI | Action > Platformer | NES | Fully Playable | 1.00 | 19 Nov 2002 | EN |
