| Zwei!! | No Alternate Title | Falcom | 20 December 2001 | Adventure | PC | N | N | Y | N |
| Zwei II | No Alternate Title | Nihon Falcom | 25 September 2008 | Role Playing > Action RPG | PC | N | N | Y | N |
| Zunou Senkan Galg | Galg | DB Soft | 14 December 1985 | Action > Shooter | NES | N | N | N | Y |
| Zugya | No Alternate Title | Sprite | 1996 | Action > Shooter | X68K | N | N | Y | N |
| Zone of the Enders | Z.O.E.: Zone of the Enders | Konami | 01 March 2001 | Action | PS2 | N | N | Y | N |
| Zombies Ate My Neighbors | No Alternate Title | Konami | 19 July 1993 | Action | SNES | N | Y | N | Y |
| Zombie Nation | Abarenbou Tengu | Meldac | 14 December 1990 | Action > Shooter | NES | N | N | Y | N |
| Zombie Hunter | No Alternate Title | Hi-Score Media Work | 03 July 1987 | Role Playing > Action RPG | NES | N | N | Y | Y |
| Zoids: Shirogane no Juukishin Liger Zero | No Alternate Title | Tomy | 15 June 2001 | Role Playing | GB | N | N | Y | N |
| Zoids: Mokushiroku | No Alternate Title | Tomy | 21 December 1990 | Strategy | NES | N | N | Y | N |
| Zoids Saga | No Alternate Title | Tomy | 30 November 2001 | Role Playing | GBA | N | N | N | N |
| Zippy Race | No Alternate Title | Sega | 1983 | Racing | SG1K | N | N | N | Y |
| Zillion | Akai Koudan Zillion | Sega | 24 May 1987 | Action | SMS | N | N | Y | Y |
| Zill O'll Infinite | No Alternate Title | Koei | 23 June 2005 | Role Playing | PS2 | N | N | Y | N |
| Zettai Muteki Raijin-Oh | Absolute Invincible Raijin-Oh | Tomy | 28 December 1991 | Action > Fighting | GB | N | N | Y | Y |
| Zero Wing | No Alternate Title | Sega | 31 May 1991 | Action > Shooter | GEN | N | N | Y | N |
| Zero Tolerance | No Alternate Title | Accolade | 1994 | Action | GEN | N | Y | N | N |
| Zen: Intergallactic Ninja | No Alternate Title | Konami | 07 March 1993 | Action > Platformer | NES | N | N | Y | N |
| Zelda II: The Adventure of Link | The Legend of Zelda 2: Link no Bouken | Nintendo | 14 February 1987 | Adventure | NES | N | Y | Y | Y |
| Zanac | No Alternate Title | Pony Canyon | 28 November 1986 | Action > Shooter | NES | N | N | Y | N |
