| Ultimate Mortal Kombat 3 | No Alternate Title | Midway | 11 October 1996 | Action > Fighting | SNES | N | N | N | Y |
| Ultimate Mortal Kombat 3 | No Alternate Title | Williams | 1996 | Action > Fighting | GEN | N | N | N | Y |
| Ultimate Qix | Volfied | Taito | 1991 | Action | GEN | N | N | Y | N |
| Ultra Baseball Jitsumeiban | No Alternate Title | Culture Brain | 28 August 1992 | Sports | SNES | N | N | Y | N |
| Ultraman Ball | No Alternate Title | Bec | 22 December 1994 | Action > Platformer | GB | N | N | Y | N |
| Ultraman Chou Toushi Gekiden | Ultraman: Legend of the Super Warrior | Angel | 26 August 1994 | Action | GB | N | N | Y | N |
| Ultraman Club: Kaijuu Daikessen!! | Ultraman Club: Great Kaiju Battle | Angel (Bandai) | 25 December 1992 | Action > Platformer | NES | N | N | Y | N |
| Umihara Kawase | No Alternate Title | TNN | 23 December 1994 | Action > Platformer | SNES | N | N | Y | N |
| Undead Line | No Alternate Title | PalSoft | 20 December 1991 | Action > Shooter | GEN | N | N | Y | N |
| Undeadline: Genjuuki | No Alternate Title | T&E Soft | 27 September 1990 | Action > Shooter | X68K | N | N | Y | N |
| Undercover Cops | No Alternate Title | Irem | 03 March 1995 | Action > Beat 'Em Up | SNES | N | N | Y | N |
| Undertale | No Alternate Title | tobyfox | 15 September 2015 | Role Playing | PC | N | N | Y | N |
| Uninvited | Akuma no Shoutaijou | Kemco | 29 September 1989 | Adventure | NES | N | N | Y | Y |
| Uniracers | Unirally | Nintendo | December 1994 | Racing | SNES | N | N | N | Y |
| Universal Soldier | No Alternate Title | Ballistic | 1992 | Action > Platformer | GEN | N | N | Y | N |
| Urban Champion | No Alternate Title | Nintendo | 14 November 1984 | Action > Fighting | NES | N | N | Y | Y |
| Urusei Yatsura: Lum no Wedding Bell | Urusei Yatsura: Lum's Wedding Bell | Jaleco | 23 October 1986 | Action > Platformer | NES | N | N | Y | N |
| Urusei Yatsura: Miss Tomobiki o Chigase! | No Alternate Title | Yanoman | 03 July 1992 | Role Playing | GB | N | N | Y | N |
| Ushio & Tora | Ushio to Tora - Shinen no Daiyou | Yutaka | 09 July 1993 | Role Playing | NES | N | N | Y | N |
| Utawarerumono | No Alternate Title | Leaf | 26 April 2002 | Strategy > Turn Based | PC | N | N | Y | N |
