| Star Force | No Alternate Title | Hudson Soft | 1985 | Action > Shooter | MSX | N | N | Y | N |
| Star Cruiser II: The Odysseus Project | No Alternate Title | Arsys | 18 June 1993 | Role Playing > Action RPG | PC98 | N | N | Y | N |
| Star Cruiser | No Alternate Title | Arsys | 14 April 1989 | Role Playing > Action RPG | X68K | N | N | Y | N |
| Star Cruiser | No Alternate Title | NCS | 21 December 1990 | Role Playing > Action RPG | GEN | N | N | Y | N |
| Stanley: The Search for Dr. Livingston | No Alternate Title | Electro Brain | October 1992 | Action > Platformer | NES | N | N | Y | N |
| Standard Daisenryaku: Shiwareta Shouri | Standard Daisenryaku: Lost Victory | Sega | 02 June 2005 | Strategy | PS2 | N | N | Y | N |
| Squashed | Ninja Jajamaru: Ginga Daisakusen | Jaleco | 29 March 1991 | Action > Platformer | NES | N | N | Y | Y |
| Square no Tom Sawyer | Square's Tom Sawyer | Square | 30 November 1989 | Role Playing | NES | N | N | Y | N |
| Sqoon | No Alternate Title | Irem | 26 June 1986 | Action > Shooter | NES | N | Y | Y | N |
| Spy vs. Spy | No Alternate Title | Kemco | 26 April 1986 | Puzzle | NES | N | N | Y | N |
| Spy vs. Spy | No Alternate Title | Sega | 20 September 1986 | Puzzle | SMS | N | N | Y | N |
| Spy Hunter | No Alternate Title | SunSoft | September 1987 | Racing | NES | N | N | N | Y |
| Spot: The Cool Adventure | McDonaldland | Virgin Interactive | 1992 | Action > Platformer | GB | N | N | Y | N |
| SpongeBob SquarePants: Battle for Bikini Bottom | No Alternate Title | THQ | 31 October 2003 | Action > Platformer | GBA | N | N | Y | N |
| Splatterhouse: Wanpaku Graffiti | Splatterhouse: Super Deformed | Namco | 31 July 1989 | Action | NES | N | N | Y | Y |
| Splatterhouse 3 | No Alternate Title | Namco | 18 March 1993 | Action > Beat 'Em Up | GEN | N | N | Y | N |
| Splatterhouse 2 | No Alternate Title | Namco | 04 August 1992 | Action > Beat 'Em Up | GEN | N | N | N | Y |
| Splatterhouse | No Alternate Title | Namco | 03 April 1990 | Action > Beat 'Em Up | TG16 | N | N | Y | Y |
| Spider-Man: Return of the Sinister Six | No Alternate Title | LJN | October 1992 | Action > Platformer | NES | N | N | N | Y |
| Spider-Man: Mysterio's Menace | Spider-Man: Mysterio no Kyoui | Activision | 19 September 2001 | Action > Platformer | GBA | N | N | Y | N |
